the differing effects of nifedipine and amlodipine, scientists conducted laboratory experiments. Both drugs work by blocking L-type calcium channels, which can shorten the action potential of cardiac cells. This shortening, in turn, could potentially trigger arrhythmias leading to cardiac arrest. The in vitro studies revealed that high doses of nifedipine caused a more pronounced shortening of action potentials than high-dose amlodipine, aligning with the population study’s results.
Expert Commentary and Future Directions
Dr. Hanno Tan, the project leader for ESCAPE-NET, emphasized that while the findings are suggestive, they need to
