this prolonged use can lead to lasting brain damage, affecting not only memory, but also motivation and overall cognitive performance, not to mention the risks of chronic irritability and depression.
Tricyclic antidepressants Although they are among the oldest treatments for depression, amitriptyline and nortriptyline are still used. While they act on serotonin reuptake to improve mood, they also possess strong anticholinergic properties.
Like the Parkinson’s disease medications mentioned above, these antidepressants inhibit acetylcholine. Elderly patients are particularly sensitive to this and may experience accelerated cognitive decline, characterized by severe confusion,
